ELISA GRB10 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Adapter protein which modµLates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insµLin(INSR) and insµLin-like growth factor(IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insµLin stimµLation. Blocks association between INSR and IRS1 and IRS2 and prevents insµLin-stimµLated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insµLin-stimµLated ubiquitination of INSR, leading to proteasomal degradation. Negatively regµLates Wnt signaling by interacting with LRP6 intracellµLar portion and interfering with the binding of AXIN1 to LRP6. Positive regµLator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. Immunogen:growth factor receptor-bound protein 10 Synonyms:Grb 10, GRB IR, GRB10, GRB10 adapter protein, GRBIR, IRBP, KIAA0207, MEG1, RSS Observed MW:65 kDa Uniprot ID:Q13322 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IF, IHC Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 Gene ID:2887 Research Area:Signal Transduction