ELISA GPR161 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Key negative regµLator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TµLP3 and the IFT-A complex to primary cilia and acts as a regµLator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown(By similarity). Immunogen:G protein-coupled receptor 161 Synonyms: Observed MW:70 kDa Uniprot ID:Q8N6U8 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200 Gene ID:23432 Research Area:Signal Transduction, Developmental biology