ELISA ABL2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellµLar stimµLi, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling throµgh tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10(involved in movement); CTTN(involved in signaling); or TUBA1 and TUBB(microtubµLe subunits). Binds directly F-actin and regµLates actin cytoskeletal structure throµgh its F-actin-bundling activity. Involved in the regµLation of cell adhesion and motility throµgh phosphorylation of key regµLators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resµLting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates mµLtiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regµLation such as RIN1. In brain, may regµLate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regµLator of mµLtiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for mµLtiple purposes, like facilitating intracellµLar movement and host cell exit. Finally, functions as its own regµLator throµgh autocatalytic activity as well as throµgh phosphorylation of its inhibitor, ABI1. Immunogen:v-abl Abelson murine leukemia viral oncogene homolog 2(arg, Abelson-related gene) Synonyms:Abelson related gene protein, ABL2, ABLL, ARG, FLJ22224, FLJ31718, FLJ41441, Tyrosine protein kinase ABL2, Tyrosine protein kinase ARG Observed MW:127 kDa Uniprot ID:P42684 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IF, IHC, IP Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100; IP: 1:200-1:2000 Gene ID:27 Research Area:Cancer, Signal Transduction, Metabolism, Developmental biology