ELISA ADAM17 anti-

Quantity :50µL Clone Number:5A1 Aliases:Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b), ADAM17, CSVP TACE Product Type:Recombinant Antibody Immunogen Species:Homo sapiens () UniProt ID:P78536 Immunogen:A syntheQuantityd peptide derived from ADAM17 Raised in: Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:20-1:200 Background:Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellµLar truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ADAM17 Research Areas:Neuroscience; Cancer; Cell biology; Metabolism; Signal transduction; Stem cells