ELISA DKK1 anti-

Quantity :50µL Clone Number:1D12 Aliases:Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK), DKK1 Product Type:Recombinant Antibody Immunogen Species:Homo sapiens () UniProt ID:O94907 Immunogen:A syntheQuantityd peptide derived from DKK1 Raised in: Reactivity: Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000 Background:Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regµLated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adµLt, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). Clonality:Monoclonal Isotype:Rabbit IgG Purification Method:Affinity-chromatography Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DKK1 Research Areas:CardiovascµLar; Developmental biology; Immunology; Stem cells