ELISA DHCR7 anti-

Quantity :50µL Clone Number: Aliases:DHCR7 antibody; D7SR antibody; 7-dehydrocholesterol reductase antibody; 7-DHC reductase antibody; EC 1.3.1.21 antibody; Delta7-sterol reductase antibody; Sterol Delta(7)-reductase antibody; Sterol reductase SR-2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UBM7 Immunogen:Fusion protein of DHCR7 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:25-1:100 Background:This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticµLum membrane and nuclear outer membrane. Mutations in this gene cause Smith-LemLi-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing resµLts in mµLtiple transcript variants that encode the same protein. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DHCR7 Research Areas:Cancer?CardiovascµLar;Metabolism;Signal transduction