ELISA GRHL3 anti-

Quantity :50µg Clone Number: Aliases:Drosophila antibody; Grainyhead like 3 antibody; Grainyhead like protein 3 homolog antibody; Grainyhead-like protein 3 homolog antibody; grhl3 antibody; GRHL3_ antibody; Sister of mammalian grainyhead antibody; Sister of mammalian grainyhead protein antibody; SOM antibody; TFCP2L4 antibody; Transcription factor CP2 like 4 antibody; Transcription factor CP2-like 4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8TE85 Immunogen:Recombinant Grainyhead-like protein 3 homolog protein (31-182AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200 Background:Transcription factor playing important roles in primary neurµLation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5\\\'-AACCGGTT-3\\\' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adµLthood, is again required for barrier repair after immune-mediated epidermal damage, regµLates distinct gene batteries in embryonic epidermal differentiation and adµLt epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurµLation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GRHL3 Research Areas:Epigenetics and Nuclear Signaling