ELISA DOCK7 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96N67 Immunogen:Recombinant Dedicator of cytokinesis protein 7 protein (1440-1671AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 \\\'Ser-15\\\' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regµLation of cortical neurogenesis throµgh the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regµLates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubµLe growth-promoting function of TACC3 (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DOCK7 Research Areas:Neuroscience; Developmental biology; Signal transduction