ELISA GRK5 anti-
Quantity :100µL
Clone Number:
Aliases:FLJ39780 antibody; FP2025 antibody; G protein coupled receptor kinase 5 antibody; G protein coupled receptor kinase GRK5 antibody; G protein-coupled receptor kinase 5 antibody; G protein-coupled receptor kinase GRK5 antibody; GPRK5 antibody; GRK-pan antibody; GRK5 antibody; GRK5_ antibody; Pan-GRK antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens ()
UniProt ID:P34947
Immunogen:SyntheQuantityd peptide derived from internal of GRK5.
Raised in:Rabbit
Reactivity:, Mouse, Rat
Tested Applications:ELISA, WB; WB:1:500-1:3000
Background:Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regµLation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regµLates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
KunapµLi P., Proc. Natl. Acad. Sci. U.S.A. 90:5588-5592(1993).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Clonality:Polyclonal
Isotype:IgG
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjµgate:Non-conjµgated
Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:GRK5
Research Areas:CardiovascµLar;Signal transduction
This kit is an essential tool for professionals seeking to conduct detailed analyses of neurotransmitter levels in urine, aiding in the understanding and management of various neurological and psychiatric conditions.
Internal Reference:
CSB-PA794868
Website URL:
/shop/csb-pa794868-elisa-grk5-anti-39732
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