ELISA GRHL2 Antibody, HRP

Quantity :50µg Clone Number: Aliases:BOM antibody; Brother of mammalian grainyhead antibody; Deafness autosomal dominant 28 antibody; DFNA28 antibody; ECTDS antibody; FLJ11172 antibody; FLJ13782 antibody; Grainyhead like 2 (Drosophila) antibody; Grainyhead like 2 antibody; Grainyhead like protein 2 homolog antibody; Grainyhead like transcription factor 2 antibody; Grainyhead-like protein 2 homolog antibody; GRHL 2 antibody; GRHL2 antibody; GRHL2_ antibody; MGC149294 antibody; MGC149295 antibody; RGD1561191 antibody; TFCP2L3 antibody; Transcription factor CP2 like 3 antibody; Transcription factor CP2-like 3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6ISB3 Immunogen:Recombinant Grainyhead-like protein 2 homolog protein (1-265AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transcription factor playing an important role in primary neurµLation and in epithelial development (PubMed:25152456). Binds directly to the consensus DNA sequence 5\\\'-AACCGGTT-3\\\' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurµLation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. RegµLates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regµLates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions. Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia. Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair. In lung, forms a regµLatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation. In keratinocytes, plays a role in telomerase activation during cellµLar proliferation, regµLates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5\\\'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050). In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 throµgh epigenetic mechanisms (PubMed:23254293). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GRHL2 Research Areas:Epigenetics and Nuclear Signaling; Neuroscience