ELISA ACO1 anti-

Quantity :50µL Clone Number: Aliases:ACO 1 antibody; ACO1 antibody; ACOC_ antibody; Aconitase 1 soluble antibody; Aconitase antibody; Aconitase1 antibody; Aconitate hydratase antibody; ACONS antibody; Citrate hydro lyase antibody; Citrate hydro-lyase antibody; Cytoplasmic aconitate hydratase antibody; Ferritin repressor protein antibody; IRE BP 1 antibody; IRE-BP 1 antibody; IREB 1 antibody; IREB1 antibody; IREBP antibody; IREBP1 antibody; Iron regµLatory protein 1 antibody; Iron responsive element binding protein 1 antibody; Iron-responsive element-binding protein 1 antibody; IRP 1 antibody; IRP1 antibody; OTTHUMP00000045233 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P21399 Immunogen:Synthetic peptide of ACO1 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, IHC; ELISA:1:2000-1:10000, IHC:1:50-1:200 Background:Aconitase 1, also known as iron regµLatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE resµLts in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellµLar iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ACO1 Research Areas:Epigenetics and Nuclear Signaling;Cancer?CardiovascµLar;Metabolism;Signal transduction