ELISA DNMT3L anti-

Quantity :50µL Clone Number: Aliases:Cytosine 5 methyltransferase 3 like protein antibody; DNA (cytosine 5 ) methyltransferase 3 like antibody; DNA (cytosine-5)-methyltransferase 3-like antibody; DNA cytosine 5 methyltransferase 3 like protein antibody; DNA methyltransferase 3 like protein antibody; DNM3L_ antibody; Dnmt 3L antibody; Dnmt3l antibody; cytosine 5 methyltransferase 3 like protein antibody; MGC1090 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UJW3 Immunogen:Fusion protein of DNMT3L Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:1000-1:2000, IHC:1:10-1:50 Background:CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thoµght to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimµLate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thoµght to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression throµgh interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DNMT3L Research Areas:Epigenetics and Nuclear Signaling