ELISA GSK3B (Ab-9) anti-

Quantity :100µL Clone Number: Aliases:Glycogen Synthase Kinase 3 Beta antibody; Glycogen synthase kinase-3 beta antibody; GSK 3 beta antibody; GSK-3 beta antibody; GSK3B antibody; GSK3B_ antibody; GSK3beta isoform antibody; Serine/threonine-protein kinase GSK3B antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P49841 Immunogen:Peptide sequence around aa.7~11 (T-T-S-F-A) derived from GSK3b. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 Background:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regµLatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Fan G, et al. (2003) J Biol Chem. 278(52): 52432-52436.Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178.Welsh, et al. (1996) Trends Cell Biol. 6: 274-279.Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141.Cross D. A, et al. (1995) Nature. 378: 785-789. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GSK3B Research Areas:Neuroscience?Cancer?CardiovascµLar;Metabolism;Signal transduction?Stem cells