ELISA DOK1 (Ab-398) anti-

Quantity :100µL Clone Number: Aliases:Docking protein 1 62kD antibody; Docking protein 1 antibody; DOK 1 antibody; DOK1 antibody; DOK1_ antibody; Downstream of tyrosine kinase 1 antibody; p62(dok) antibody; P62DOK antibody; pp62 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99704 Immunogen:Peptide sequence around aa.396~400 (P-I-Y-D-E) derived from p62Dok. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 Background:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of mµLtimolecµLar signaling complexes. DOK1 appears to be a negative regµLator of the insµLin signaling pathway. ModµLates integrin activation by competing with talin for the same binding site on ITGB3. Michael J. Wick,et,al. (2001) J. Biol. Chem; 276: 42843 - 42850. PaµL D. Simoncic, et,al. (2006) Mol. Cell. Biol; 26: 4149 - 4160. Nadia Dub Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:DOK1 Research Areas:Cancer?CardiovascµLar;Metabolism;Signal transduction