ELISA GPR161 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:GPR161 antibody; G-protein coupled receptor 161 antibody; G-protein coupled receptor RE2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8N6U8 Immunogen:Recombinant G-protein coupled receptor 161 protein (1-28AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Key negative regµLator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TµLP3 and the IFT-A complex to primary cilia and acts as a regµLator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GPR161 Research Areas:Others