ELISA GRK6 anti-

Quantity :50µL Clone Number: Aliases:FLJ32135 antibody; G protein coupled receptor kinase 6 antibody; G protein coupled receptor kinase GRK6 antibody; G protein-coupled receptor kinase 6 antibody; G protein-coupled receptor kinase GRK6 antibody; Gprk6 antibody; Grk6 antibody; GRK6_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P43250 Immunogen:Recombinant G protein-coupled receptor kinase 6 protein (1-170AA) Raised in:Rabbit Reactivity:, Rat Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 Background:Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GRK6 Research Areas:CardiovascµLar; Signal transduction