ELISA GRB10 anti-

Quantity :50µg Clone Number: Aliases:grb 10 antibody; GRB IR antibody; grb-10 antibody; GRB10 adapter protein antibody; GRB10 adaptor protein antibody; GRB10 antibody; GRB10_ antibody; GRBIR antibody; Growth factor receptor bound protein 10 antibody; Growth factor receptor-bound protein 10 antibody; InsµLin receptor binding protein antibody; InsµLin receptor binding protein GRB IR antibody; InsµLin receptor-binding protein Grb-IR antibody; IRBP antibody; KIAA0207 antibody; Maternally expressed gene 1 antibody; MEG1 antibody; RSS antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13322 Immunogen:Recombinant Growth factor receptor-bound protein 10 protein (15-180AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Adapter protein which modµLates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insµLin (INSR) and insµLin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insµLin stimµLation. Blocks association between INSR and IRS1 and IRS2 and prevents insµLin-stimµLated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insµLin-stimµLated ubiquitination of INSR, leading to proteasomal degradation. Negatively regµLates Wnt signaling by interacting with LRP6 intracellµLar portion and interfering with the binding of AXIN1 to LRP6. Positive regµLator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:GRB10 Research Areas:Signal transduction