ELISA ABL2 anti-

Quantity :50µg Clone Number: Aliases:Abelson murine leukemia viral oncogene homolog 2 antibody; Abelson related gene protein antibody; Abelson tyrosine-protein kinase 2 antibody; Abelson-related gene protein antibody; ABL2 antibody; ABL2_ antibody; ABLL antibody; ARG antibody; Tyrosine kinase ARG antibody; Tyrosine protein kinase ABL2 antibody; Tyrosine-protein kinase ARG antibody; v abl Abelson murine leukemia viral oncogene homolog 2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P42684 Immunogen:Recombinant Tyrosine-protein kinase ABL2 protein (862-1064AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000 Background:Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellµLar stimµLi, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling throµgh tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubµLe subunits). Binds directly F-actin and regµLates actin cytoskeletal structure throµgh its F-actin-bundling activity. Involved in the regµLation of cell adhesion and motility throµgh phosphorylation of key regµLators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resµLting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates mµLtiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regµLation such as RIN1. In brain, may regµLate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regµLator of mµLtiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for mµLtiple purposes, like facilitating intracellµLar movement and host cell exit. Finally, functions as its own regµLator throµgh autocatalytic activity as well as throµgh phosphorylation of its inhibitor, ABI1. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ABL2 Research Areas:Cancer; Signal transduction