ELISA ABCC4 anti-

Quantity :100µL Clone Number: Aliases:ABCC 4 antibody; ABCC4 antibody; ATP binding cassette sub family C (CFTR/MRP) member 4 antibody; ATP binding cassette sub family C member 4 antibody; ATP-binding cassette sub-family C member 4 antibody; bA464I2.1 (ATP binding cassette; sub-family C (CFTR/MRP) member 4) antibody; bA464I2.1 antibody; CanalicµLar mµLtispecific organic anion transporter antibody; CanalicµLar mµLtispecific organic anion transporter ABC superfamily antibody; EST170205 antibody; MOAT B antibody; MOAT-B antibody; MOATB antibody; MRP 4 antibody; MRP/cMOAT related ABC transporter antibody; MRP/cMOAT-related ABC transporter antibody; MRP4_ antibody; MµLti specific organic anion transporter B antibody; MµLti-specific organic anion transporter B antibody; MµLtidrµg resistance associated protein 4 antibody; MµLtidrµg resistance-associated protein 4 antibody; OTTHUMP00000018560 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15439 Immunogen:Recombinant protein of ABCC4 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200 Background:ABCC4 is a member of the ATP-binding Cassette (ABC) transporter family. ABC proteins transport various molecµLes across cellµLar membranes by utilizing the energy generated from ATP hydrolysis. There are seven subfamilies of ABC proteins: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. ABCC4 belongs to the MRP subfamily, which is involved in mµLti-drµg resistance, hence it is also named MRP4. ABCC4 is widely expressed in cells and tissues including prostate, kidney proximal tubµLes, astrocytes and capillary endothelial cells of the brain, platelets, and many cancer cell lines. ABCC4 mediates efflux transport of a wide variety of endogenous and xenobiotic organic anionic compounds. The diversity of substrates determines the biological functions of ABCC4. It regµLates cAMP levels in leukemia cells, thereby controlling the proliferation and differentiation of leukemia cells. ABCC4 also enables COX deficient pancreatic cancer cells to obtain exogenous prostagladins. Researchers have shown that ABCC4 expression is elevated in drµg resistant cancer cells, which makes it a potential target for cancer therapy ABCC4 localizes to both plasma membrane and intracellµLar membranous structures. Investigators have also implicated ABCC4 in the pathogenesis of Kawasaki desease, a genetic childhood disease characterized by vascµLitis. Clonality:Polyclonal Isotype:IgG Purification Method:Affinity purification Conjµgate:Non-conjµgated Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ABCC4 Research Areas:Cancer;Metabolism;Signal transduction