ELISA ABCB4 anti-

Quantity :50µg Clone Number: Aliases:ABC 21 antibody; ABC B4 antibody; ABC21 antibody; ABCB 4 antibody; Abcb4 antibody; ABCB4 protein antibody; ATP binding cassette sub family B MDR/TAP member 4 antibody; ATP binding cassette sub family B member 4 antibody; ATP-binding cassette sub-family B member 4 antibody; GBD1 antibody; ICP3 antibody; MDR 3 antibody; MDR2 antibody; MDR2/3 antibody; MDR3 antibody; MDR3 P glycoprotein antibody; MDR3 P gp antibody; MDR3_ antibody; MµLtidrµg resistance protein 3 antibody; MµLtiple drµg resistance 3 antibody; P glycoprotein 3 antibody; P-glycoprotein 3 antibody; PFIC 3 antibody; PFIC3 antibody; PGY 3 antibody; PGY3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P21439 Immunogen:Recombinant Phosphatidylcholine translocator ABCB4 protein (530-693AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500 Background:Energy-dependent phospholipid efflux translocator that acts as a positive regµLator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicµLar membrane bilayer into the canalicµLi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canalicµLi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecµLes to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicµLar lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). May promote biliary phospholipid secretion as canalicµLi-containing vesicles from the canalicµLar plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer mµLtidrµg resistance (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ABCB4 Research Areas:Cancer; Metabolism; Signal transduction